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FACULTY RESEARCH PAGES, ALPHABETICAL LISTING

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Karen Anderson § (Pharmacology)

Susan Baserga Ribonucleoprotein and protein complexes involved in eukaryotic ribosome biogenesis.

Richard Baxter § (Chemistry)

Thomas Biederer Molecular basis of synapse formation in the vertebrate central nervous system.

Ronald Breaker § (MCDB). Nucleic acids biochemistry and engineering, riboswitch and noncoding RNA discovery and analysis.

Gary Brudvig § (Chemistry). Photosynthetic water oxidation; metalloproteins; biological electron-transfer reactions.

Donald M. Crothers ** (Chemistry)

Enrique M. De La Cruz Mechanisms of energy transduction and allostery in molecular motors. Cooperative actin filament interactions.

Daniel DiMaio § (Genetics). Mechanisms of viral carcinogenesis and replication; molecular basis of cell growth and senescence; transmembrane protein interactions.

Don Engelman Folding and oligomerization of membrane proteins: structural motifs, association energies, design principles.

Alan Garen Molecular genetics of Drosophila development; inactivation of cellular and viral functions by integration of new genes into the genome.

Mark Gerstein Bioinformatics: Large-scale analysis of genome sequences, macromolecular structures and expression data.

Nigel Grindley Mechanisms of site-specific recombination and DNA transposition. Mechanistic studies of DNA polymerases.

Mark Hochstrasser Cell regulation by the ubiquitin-proteasome system. Dynamics of intracellular protein tagging by ubiquitin and SUMO.

Catherine Joyce* Mechanistic studies of DNA polymerases.

Michael Koelle G protein signaling in the C. elegans nervous system.

Anthony Koleske Regulation of cytoskeletal dynamics by adhesion:  roles in cell migration, tumor invasion and neurodegeneration.

William Konigsberg Assembly, structure and function of DNA replication complexes.

Peter Lengyel**

J. Patrick Loria § (Chemistry). Investigation of enzyme motions by solution NMR spectroscopy.

Nancy Moran § (Ecology & Evolutionary Biology)

I. George Miller § (Pediatrics & Epidemiology). Molecular biology of oncogenic human herpesviruses, including Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus.

Andrew Miranker Protein folding, misfolding and assembly of pathogenic complexes.

Yorgo Modis The structural basis of innate immune sensing and viral membrane fusion.

Peter Moore ** (Chemistry). Structure and function of ribosomes.

Thomas Pollard § (MCDB). Molecular mechanisms of actin-based cellular motility and of cytokinesis.


Lynne Regan Protein structure, folding and design; protein-protein and protein-RNA interactions.

Elizabeth Rhoades Characterization of protein conformation/dynamics; protein-protein interactions, and protein-membrane interactions.

Frederic M. Richards**

Professor Richards passed away on January 11th, 2009

David Schatz § (Immunobiology). Mechanism and regulation of V(D)J recombination and somatic hypermutation during lymphocyte development; mechanisms of DNA repair; functions of the RAG1, RAG2, and AID proteins.

Christian Schlieker Protein quality control and its relation to viral pathogenesis.

Robert G. Shulman**

Chuck Sindelar Mechanisms of cytoskeletal motors and depolymerases through high-resolution cryo-EM, X-ray crystallography, and other biophysical methods; methods development related to high-resolution cryo-EM.

Dieter Söll Genomics of the translation apparatus.

Mark Solomon Biochemical regulation of the eukaryotic cell cycle.clar.

Joan Steitz Structure and function of small ribonucleoproteins in eukaroytes; RNA processing and RNA stability.

Thomas Steitz X-ray diffraction and molecular biological structure/function studies of proteins and nucleic acids involved in replication, recombination, transcription and translation.

Scott Strobel Structure and function of RNA: understanding the catalytic mechanism and tertiary structure of RNA enzymes.

William Summers History and philosophy of science; science education.

Patrick Sung Dissecting the mechanism of DNA double-stranded break repair in eukaryotes.

Hongwei Wang Structure and function of macromolecular assemblies involved in RNA metabolism and cytoskeleton dynamics.

Kenneth R. Williams * Mass spectrometric identification of proteins and their post-translational modifications, DNA microarray analysis of mRNA expression, protein:nucleic acid interactions.

Sandra Wolin § (Cell Biology). Noncoding RNA surveillance; RNA chaperones; RNA handling during stress.

Yong Xiong Structures and functions of host factors that restrict viral infection.