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FACULTY RESEARCH PAGES, ALPHABETICAL LISTING

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Susan Baserga. Ribonucleoprotein and protein complexes involved in eukaryotic ribosome biogenesis.

Thomas Biederer. Molecular basis of synapse formation in the vertebrate central nervous system.

Ronald Breaker § (MCDB). Nucleic acids biochemistry and engineering, riboswitch and noncoding RNA discovery and analysis.

Gary Brudvig § (Chemistry). Photosynthetic water oxidation; metalloproteins; biological electron-transfer reactions.

Donald M. Crothers ** (Chemistry)

Enrique M. De La Cruz. Mechanisms of energy transduction and allostery in molecular motors. Cooperative actin filament interactions.

Daniel DiMaio. § (Genetics). Mechanisms of viral carcinogenesis and replication; molecular basis of cell growth and senescence; transmembrane protein interactions.

Don Engelman. Folding and oligomerization of membrane proteins: structural motifs, association energies, design principles.

Alan Garen. Molecular genetics of Drosophila development; inactivation of cellular and viral functions by integration of new genes into the genome.

Mark Gerstein. Bioinformatics: Large-scale analysis of genome sequences, macromolecular structures and expression data.

Sankar Ghosh § (Immunobiology). Regulation of transcription, role of cytokines and mechanisms of signal transduction in immune cells.

Nigel Grindley. Mechanisms of site-specific recombination and DNA transposition. Mechanistic studies of DNA polymerases.

Andrew D. Hamilton § (Chemistry).

Mark Hochstrasser. Cell regulation by the ubiquitin-proteasome system. Dynamics of intracellular protein tagging by ubiquitin and SUMO.

Catherine Joyce.* Mechanistic studies of DNA polymerases.

Michael Koelle. G protein signaling in the C. elegans nervous system.

Anthony Koleske. Biochemical regulation of cell migration on extracellular matrix.

William Konigsberg. Assembly, structure and function of DNA replication complexes.

Peter Lengyel.**

I. George Miller § (Pediatrics & Epidemiology). Molecular biology of oncogenic human herpesviruses, including Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus.

Andrew Miranker. Protein folding, misfolding and assembly of pathogenic complexes.

Yorgo Modis. The structural basis of innate immune sensing and viral membrane fusion.

Peter Moore § (Chemistry). Structure and function of ribosomes.

Thomas Pollard § (MCDB). Molecular mechanisms of actin-based cellular motility and of cytokinesis.

Anna Marie Pyle. RNA tertiary structure and folding of group II intron ribozymes; Translocation and unwinding mechanisms of RNA helicase enzymes; Computational analysis of RNA structure.

Lynne Regan. Protein structure, folding and design; protein-protein and protein-RNA interactions.

Elizabeth Rhoades. Characterization of protein conformation/dynamics; protein-protein interactions, and protein-membrane interactions.

Frederic M. Richards.**

Gaston L. Schmir.**

Robert G. Shulman.**

Michael Snyder § (MCDB). Regulatory Networks: Large-scale analysis of eucaryotic genomes and proteomes.

Dieter Söll. Genomics of the translation apparatus.

Mark Solomon. Biochemical regulation of the eukaryotic cell cycle.

Joan Steitz. Structure and function of small ribonucleoproteins in eukaroytes; RNA processing and RNA stability.

Thomas Steitz. X-ray diffraction and molecular biological structure/function studies of proteins and nucleic acids involved in replication, recombination, transcription and translation.

Scott Strobel. Structure and function of RNA: understanding the catalytic mechanism and tertiary structure of RNA enzymes.

William Summers. History and philosophy of science; science education.

Patrick Sung. Dissecting the mechanism of DNA double-stranded break repair in eukaryotes.

Vinzenz Unger. Structure and function of integral membrane proteins and membrane associated scaffolds.

Kenneth R. Williams.* Mass spectrometric identification of proteins and their post-translational modifications, DNA microarray analysis of mRNA expression, protein:nucleic acid interactions.

Sandra Wolin § (Cell Biology). RNA folding and misfolding inside cells; RNA quality control; RNA chaperones.

Yong Xiong. Structures and functions of host factors that restrict viral infection.