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ANDREW D. HAMILTON

When it comes to how biological molecules recognize and interact with one another, science is long on theory and short on concrete examples. The Hamilton lab fills the gap, designing chemical analogs to model the behavior of naturally occurring biological molecules.

Selected Publications
Choi, K.; Hamilton, A. D. "Selective Anion Binding by a Macrocycle with Convergent Hydrogen Bonding Functionality" J. Am. Chem. Soc. 2001, 123. 2456-2457.

Lee, C. S.; Lee, K. I.; Hamilton, A. D. "Constrained Analogs of Methionine: Asymmetric synthesis of c-angle restricted methionine derivatives through [3.1.0]-g-lactone cyclopropane ring opening" Tetrahedron Lett. 2001, 211-213.

Sun, J.; Li, B.; Lee, C. S.; Nam, S.; Coppola, D.; Hamilton, A. D.; Dou, Q. P.; Sebti, S. M. "CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces Apoptosis and Inhibits the Growth of Human Lung Adenocarcinoma A-549 in Nude Mice" Cancer Res. 2001, 61, 1280-1288.

Orner, B. P.; Ernst, J. T.; Hamilton, A. D. "Towards Proteomimetics: Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an a-Helix" J. Am. Chem. Soc. 2001, 123, 5382-5383.

Ohkanda, Lockman, J. W.; Yokoyama, K.; Gelb, M. H.; Croft, S. L.; Kendrick, H.; Harrell, M. H.; Feagin, J. E.; Blaskovich, M. A.; Sebti, S. M.; Hamilton, A. D. "Peptidomimetic Inhibitors of Protein Farnesyltransferase Show Potent Antimalarial Activity" Bioorg. Med. Chem. Lett. 2001, 11, 761-764.

Last Updated 2001