Postdoctoral Fellowship in Structural Biology (1/07)

A postdoctoral position is available in the laboratory of Prof. Yorgo Modis in the Department of Molecular Biophysics and Biochemistry at Yale University to study the molecular basis of pathogen recognition by the innate immune system.

Most plants and animals rely on their innate immune system to alert them of an impending infection, and mount a defensive response against the invading pathogen. These immune responses are critically dependent on the Toll-like receptors (TLRs). Remarkably, TLRs recognize a wide variety of structural motifs but share the same overall architecture in their extracellular domain. Our structural studies will aim to determine how this fold recognizes such a large variety of structural motifs, and how this recognition event is translated into a signal in the cell that elicits an immune response.

Yorgo Modis is a member of the Center for Structural Biology at Yale University. The Center includes world-renowned investigators and provides access to state-of-the-art equipment for macromolecular structure determination including a robotic liquid handling system for protein crystallization, microfocus X-ray generators, and high-speed computing.

The position will be fully funded by Yale University in accordance with NIH guidelines. We seek a highly motivated individual, preferably with experience in molecular biology, protein biochemistry and eukaryotic cell culture. Selection will be independent of race, religion or gender.

Please send a CV and the names and contact details of three references to

Yorgo Modis
Yale University
The Bass Center, Room 430
266 Whitney Avenue
New Haven, CT 06520
U.S.A.


Postdoctoral Position in Structural Biology (1/07)
 
A postdoctoral position is available in the laboratory of Dr. Yong Xiong in Department of Molecular Biophysics and Biochemistry at Yale University. The lab aims to determine the mechanisms by which host cellular factors suppress viral infections, and mechanisms of fatty acid synthesis. The structural information obtain will be used to design anti-viral and antimicrobial compounds. For more information, please visit: http://www.csb.yale.edu/people/xiong/frontdoor.html
 
The position will be fully funded by Yale University in accordance with NIH guidelines. The candidate should have a strong background in molecular biology and protein biochemistry, and should be highly motivated for career development using structural biology methods. Experience in eukaryotic expression systems would be a plus.

Our lab is at the Center for Structural Biology at Yale University, which has a long tradition of research excellence and a stimulating environment that includes world-renowned groups as well as young investigators. The center has state-of-the-art equipment, including crystallization robots, microfocus X-ray generators, and high-speed computing.
 
Please send a CV, a one-page research experience summary and contact information of three references to: yong.xiong@yale.edu